The Crelm package provides a relatively simple API around the CFFI system. Give it C code or source files, it gives you a package with bindings to functions and structs. Easiest way to get started is hack up the examples in the repo.
pip3 install crelm
from crelm import Factory
paste = Factory(debug=False, verbose=True).create_Tube('add2') \
.add_source_text('int add2(int a, int b) { return a + b; }') \
.squeeze()
print(f'2 + 3 = {paste.add2(2, 3)}')