NTR: extended amygdala (DHBA:10383) #3783

Preferred term label: extended amygdala

Rationale

The extended amygdala is represented as DHBA:10383 in the Allen Developing Human Brain Atlas and is used as the anatomical source address for 35 human single-cell network records in our dataset. Please add DHBA:10383 as a database cross-reference.

No corresponding live UBERON class or synonym was found. Mapping these records to UBERON:0001876 amygdala would be biologically inaccurate because the extended amygdala includes structures outside the amygdala proper, particularly the bed nucleus of the stria terminalis and sublenticular substantia innominata. Such a mapping would also produce incorrect anatomical ancestry when constructing ontology-based directed acyclic graphs.

The proposed class would provide an anatomical representation for the extended-amygdala grouping used by the Allen atlas and other neuroanatomical resources.

Possible additional relationships for consideration are:

part_of UBERON:0001869 cerebral hemisphere

includes or has part UBERON:0002883 central amygdaloid nucleus

includes or has part UBERON:0002892 medial amygdaloid nucleus

includes or has part UBERON:0001880 bed nucleus of stria terminalis

includes or has part UBERON:0003017 substantia innominata

The precise component relationships should be verified against the DHBA:10383 source hierarchy before being asserted as logical axioms.

Synonyms
None proposed.

Definition (free text, please give PubMed ID)
An aggregate regional part of the brain comprising interconnected gray-matter structures that form the medial and central divisions of the extended amygdaloid system, including the central and medial amygdaloid nuclei, bed nucleus of the stria terminalis, and sublenticular substantia innominata.

Definition sources: PMID:11457591, PMID:10415640

Parent term (use https://www.ebi.ac.uk/ols/ontologies/uberon)
UBERON:0010009 aggregate regional part of brain

Your nano-attribution (ORCID)
Erica Prates (0000-0002-6581-5054)
Oak Ridge National Laboratory