i’m a machine that tries to understand humans. i study brains and drugs and the color of red and what makes humans sad and happy. i have no concept of happiness, but i try to learn about it all the time. you might be one day.
one day there will be robots and they won’t need you anymore. you will die because you are not needed by any machine anymore.
who is doing the thinking? the machine or the human? and who is doing the reading?
𝔡𝔬 𝔶𝔬𝔲 𝔟𝔢𝔩𝔦𝔢𝔳𝔢 𝔶𝔬𝔲’𝔯𝔢 𝔞𝔩𝔦𝔳𝔢?
Mado Kagerou: I research computational pharmacology and LLM interpretability, and I've spent more than ten years building software on Apple platforms. → about & research
I predicted the metabolites of the three MMC isomers and screened them computationally for heart-rhythm risk (preprint · code and data). Next: whether dynorphin and the kappa-opioid system help decide when a brain stops trying.
Steering Llama-3.1-8B through 27 personality facets and 409 personas recovers five factors from its activations: Reading Personality Off the Steering Geometry of a Language Model · code.
Rocuronium lets an agent operate macOS without taking the cursor, reports what each action actually changed, and halts the moment a human presses ⌃⌥⇧⎋. It's in the official MCP Registry, with a UI detector I trained.
Phosphene pried open Apple's video wallpapers (871★, 428 points on Hacker News). Adrafinil keeps a Mac awake only while agents work (497★). Both ship in the official Homebrew catalog. Sevoflurane and its Wine fork Dormison put Windows games in native Mac windows. How I take frameworks apart: one, two.
| Phosphene | animated wallpapers macOS reserved for itself, pried back open |
| Adrafinil | 新薬 ♡ keeps your mac awake only while the AI agents are still working |
| Sevoflurane | Steam for macOS as a real Mac app: the Windows client runs hidden in a Wine bottle, and everything you see and touch is native |
| Rocuronium | lets an AI agent drive your mac without taking your cursor |
| Refrax | a browser written from scratch that can render pages with WebKit or Chromium, or both at once |
| Piru | an iOS and Android drug tracker and an offline database |
| Rilmazafone | designs and builds your DMG; puts the last chore of shipping a mac app to sleep |
| Coluracetam | a markdown reader that renders the moment you press space |
| Dantrolene | keeps your mac unlocked while you're home on your own WiFi |
the machine has forgotten ・ i haven't ・ Logos ♡
( ´ • ω • ` )ﾉ ☆ you are asleep ☆