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Separate omnibus and post-hoc differential regulation results - #93

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enryH merged 10 commits into
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copilot/multiomics-analytics-groupacore-91-check-different
Oct 8, 2026
Merged

enryH merged 10 commits into
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copilot/multiomics-analytics-groupacore-91-check-different

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Copilot AI commented Oct 2, 2026 •

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Multi-group differential regulation needs to distinguish the overall omnibus test from pairwise post-hoc comparisons. The output now exposes each test’s adjusted significance separately for plotting and downstream analysis.

  • Result fields: rejected remains the omnibus decision; posthoc rejected records the pairwise decision.
  • Correction and schemas: Accumulate corrected pairwise results and validate the post-hoc decision in ANOVA and ANCOVA outputs. Method identifies the selected omnibus test.
  • Example: Update the multi-group example to plot pairwise fold changes against pairwise p-values.
omnibus = results[["identifier", "F-statistics", "padj", "rejected"]].drop_duplicates()
pairwise = results[
    ["identifier", "group1", "group2", "posthoc pvalue adj", "posthoc rejected"]
]

Copilot AI and others added 2 commits October 2, 2026 13:33
Co-authored-by: enryH <2833836+enryH@users.noreply.github.com>
Co-authored-by: enryH <2833836+enryH@users.noreply.github.com>
Copilot AI changed the title [WIP] Distinguish omnibus and posthoc results for analysis Separate omnibus and post-hoc differential regulation results Oct 2, 2026
Copilot AI requested a review from enryH October 2, 2026 13:36
@enryH
enryH marked this pull request as ready for review October 2, 2026 14:21
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Reviewed commit: 194ace8e07

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Comment thread docs/examples_single_analysis/diff_regulation_anova_more_than_two_groups.py Outdated
@enryH
enryH merged commit 16d7488 into main Oct 8, 2026
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@enryH
enryH deleted the copilot/multiomics-analytics-groupacore-91-check-different branch October 8, 2026 07:39
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Check differential regulation results table for more than two groups

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