Medical Student & Bioinformatics Researcher · Università degli Studi di Napoli Federico II & TIGEM
Computational oncology, spatial multi-omics, reaction-diffusion biophysics & reproducible software.
Founder of Web3 protocol @arbincept.

🌐 The Cave (Research Portfolio) · 📝 Substack · 💼 LinkedIn · 🆔 ORCID · 🤗 Hugging Face

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If you arrived here from the 3D Reaction-Diffusion Tumor Cord Simulation:

• 🏰 Enter Luca's Cave (Flagship Research Hub & Interactive 3D Lab) — full research ecosystem, 3D lab, multi-cohort validations & systems.
• 🎬 Watch Part 1 Short (YouTube Shorts) — perivascular drug decay, DTP dormancy, and cytokine awakening.
• 🎬 Watch Part 2 Short (YouTube Shorts) — collagen pore steric entrapment (<11 nm) and ctDNA trans-endothelial entry.
• 🎬 Watch Part 3 Short (YouTube Shorts) — CAF microvessel compression, arrested convection, and persister survival.
• 🎬 Watch Part 4 Short (YouTube Shorts) — monoclonal antibodies penetrating microvascular niches to bind tumor cells.
• 🎬 Watch Part 5 Short (YouTube Shorts) — 5.5-month analytical lead time: liquid biopsy (ctDNA MRD+) vs. CT imaging.
• ⭐ Inflammatory Onco-Physics Flagship Repository — reaction-diffusion continuum solver, Volterra memory functional, bedside HTBI engine & 11 cohorts ($N=3,461$).
• ⚡ 1-Click Google Colab Notebook (Pro T4 GPU) — run the full simulation and clinical survival regressions in your cloud browser.
• 📄 4-Page Executive Technical Memorandum (IFOM Discussion) — concise biophysical memorandum on DTP sanctuaries and ctDNA steric constraints.

Author-reviewed clinical & biophysical lay summary (Conditions for Pharmacological Sanctuaries in Perivascular Tumour Cords, rs-11530312) by Dr. Luc Hendriks, PhD & Luca Celebrano:

🇬🇧 Read English Plain-Language Digest ↗

Also translated into 11 languages:
🇮🇳 हिन्दी (Hindi) · 🇮🇹 Italiano · 🇪🇸 Español · 🇫🇷 Français · 🇩🇪 Deutsch · 🇵🇹 Português · 🇨🇳 中文 · 🇯🇵 日本語 · 🇰🇷 한국어 · 🇸🇦 العربية · 🇳🇱 Nederlands

A Reaction-Diffusion Theory of Microvascular Pharmacological Sanctuaries and Inflammatory Pre-conditioning Explains Post-Adjuvant Relapse Dynamics Across 3,461 Patients.

• Setting & Scope: Explains post-cessation recurrence and ctDNA shedding kinetics across 11 clinical cohorts ($N=3,461$) through continuous reaction-diffusion (Bessel $K_0$) and hereditary Volterra memory functional.
• Status: Springer Nature Master Monograph (26 pages) / Zenodo Permanent Archive.
• Access: Zenodo Master Archive (DOI: 10.5281/zenodo.24118328) · 1-Click Google Colab (Pro T4 GPU) · Full Monograph PDF · Supplementary Information PDF · Executive Memorandum PDF · Shorts Quintilogy (Part 1-5)

An in silico biophysical reaction-diffusion theory of pharmacological sanctuaries, post-ADAURA recurrence kinetics, and the prospective SG-ADAURA trial protocol hypothesis.

• Status: Under review at Scientific Reports (Nature Portfolio, Editor Assigned).
• Access: Research Square Preprint (DOI: 10.21203/rs.3.rs-11530312/v1) · Zenodo Master Archive · Full Manuscript PDF · Interactive Slides · Poster · bio.tools

Evidence-linked translational models, exploratory GIST phenotype scoring, candidate registry, and Composite Resistance Index (CRI) audit tools.

• Status: Published on Research Square.
• Access: Preprint (DOI: 10.21203/rs.3.rs-11633521/v1) · Zenodo Archive · bio.tools

Spatial evolutionary game-theoretic assay for inferring subclonal payoff matrices and adaptive therapy dynamics.

• Access: Live Assay Portal · Zenodo Archive · bio.tools

Subcellular transport boundaries in EGFR-mutant NSCLC via 10x Visium HD (officially curated in awesome-single-cell).

Low-cost Attention-MIL pathology AI for spatial vascular decoupling on routine H&E whole-slide images.

• Access: Live Portal · bio.tools

Cylindrical Bessel K₀ reaction-diffusion solver and MSKCC survival validation (N = 604).

• Access: Live Portal · GHCR Docker Image

conda install -c bioconda spatial-continuum insitugame spatial-sanctuary
pip install spatial-continuum

• Package Registries: PyPI · Bioconda
• Stack: Python (NumPy, SciPy, pandas, scikit-learn, PyTorch, lifelines) · Nextflow DSL2 (nf-core) · Snakemake · Galaxy (IUC) · Bioconda · Docker/Singularity · TypeScript · Three.js

Interactive 3D cardiology & pulmonology learning platform built with React, TypeScript, Three.js, and Tailwind CSS (3D cardiac anatomy, ECG telemetry simulator, auscultation audio library).
👉 Launch MedTerminal ↗

Selected merged pull requests in upstream repositories:

• Snakemake — official wrappers: bio/spatialcontinuum #6233.
• Bioconda — scientific recipes: spatial-continuum #70930, insitugame #70893, spatial-sanctuary #70840.
• nf-core/modules — Nextflow modules: spatialcontinuum/cricalc #13487, insitugame #13471, ABRA2 #13039.
• awesome-single-cell — spatial transcriptomics curation #399.
• Awesome-AI4DigitalPathology — computational pathology tools #28.
• Developer Portfolios — portfolio showcase #4452.
• Angular — DevTools signal inspection fix #70986.
• viem — chain configurations #5108.
• Ethereum Lists — RPC additions #8730.
• DefiLlama — fee telemetry adapters #9838.

• 🏛️ Medical School: Department of Clinical Medicine and Surgery, Università degli Studi di Napoli Federico II.
• 🧬 Bioinformatics Thesis: TIGEM (Telethon Institute of Genetics and Medicine).
• 🎓 Academic Email: l.celebrano@studenti.unina.it
• ✉️ Personal Email: luca.celebrano1@gmail.com