diff --git a/Zend/zend_portability.h b/Zend/zend_portability.h
index 4906c2947cc5..1c600e3c91d5 100644
--- a/Zend/zend_portability.h
+++ b/Zend/zend_portability.h
@@ -586,8 +586,8 @@ extern "C++" {
 
 /* Memory sanitizer is incompatible with ifunc resolvers. Even if the resolver
  * is marked as no_sanitize("memory") it will still be instrumented and crash. */
-#if __has_feature(memory_sanitizer) || __has_feature(thread_sanitizer) || \
-	__has_feature(dataflow_sanitizer)
+#if defined(PHP_DISABLE_IFUNC) || __has_feature(memory_sanitizer) || \
+	__has_feature(thread_sanitizer) || __has_feature(dataflow_sanitizer)
 # undef HAVE_FUNC_ATTRIBUTE_IFUNC
 #endif
 
diff --git a/configure.ac b/configure.ac
index b5dcf0da17f8..5f9334f0b5a5 100644
--- a/configure.ac
+++ b/configure.ac
@@ -296,6 +296,10 @@ AS_VAR_IF([PHP_BINARIES],,
 dnl Exit early.
 AS_VAR_IF([PHP_INSTALLED_SAPIS],, [AC_MSG_ERROR([Nothing to build.])])
 
+AS_VAR_IF([php_tsrm_dlopened_sapi], [yes], [
+  AC_DEFINE([PHP_DISABLE_IFUNC], [1], [Define to disable IFUNC resolvers.])
+])
+
 dnl Add POSIX threads compilation and linker flags when thread safety is enabled
 dnl with either the '--enable-zts' configure option or automatically enabled by
 dnl PHP SAPIs. For example, Apache SAPI.