diff --git a/src/EFCore.PG/Infrastructure/Internal/NpgsqlOptionsExtension.cs b/src/EFCore.PG/Infrastructure/Internal/NpgsqlOptionsExtension.cs
index b8ff030f3..7d1a7caf3 100644
--- a/src/EFCore.PG/Infrastructure/Internal/NpgsqlOptionsExtension.cs
+++ b/src/EFCore.PG/Infrastructure/Internal/NpgsqlOptionsExtension.cs
@@ -267,11 +267,26 @@ public virtual NpgsqlOptionsExtension WithEnumMapping(
         nameTranslator ??= NpgsqlConnection.GlobalTypeMapper.DefaultNameTranslator;
 #pragma warning restore CS0618
 
-        clone._enumDefinitions.Add(new EnumDefinition(clrType, enumName, schemaName, nameTranslator));
+        var enumDefinition = new EnumDefinition(clrType, enumName, schemaName, nameTranslator);
+
+        // The same mapping is frequently configured more than once, e.g. when both a context and a context factory are registered
+        // in DI with the same configuration lambda (both lambdas configure the same options). Ignore such duplicates; definitions
+        // which actually differ are kept, and are reported when the mapping is looked up.
+        if (!clone._enumDefinitions.Any(d => IsSameEnumMapping(d, enumDefinition)))
+        {
+            clone._enumDefinitions.Add(enumDefinition);
+        }
 
         return clone;
     }
 
+    private static bool IsSameEnumMapping(EnumDefinition existing, EnumDefinition added)
+        => existing.ClrType == added.ClrType
+            && existing.StoreTypeName == added.StoreTypeName
+            && existing.StoreTypeSchema == added.StoreTypeSchema
+            && existing.Labels.Count == added.Labels.Count
+            && existing.Labels.All(l => added.Labels.TryGetValue(l.Key, out var label) && label == l.Value);
+
     /// <summary>
     ///     Returns a copy of the current instance configured to use the specified administrative database.
     /// </summary>
diff --git a/test/EFCore.PG.Tests/NpgsqlDbContextOptionsExtensionsTest.cs b/test/EFCore.PG.Tests/NpgsqlDbContextOptionsExtensionsTest.cs
index 27d4446bd..8fef741e9 100644
--- a/test/EFCore.PG.Tests/NpgsqlDbContextOptionsExtensionsTest.cs
+++ b/test/EFCore.PG.Tests/NpgsqlDbContextOptionsExtensionsTest.cs
@@ -145,5 +145,63 @@ public void Varying_data_source_connection_strings_do_not_cause_multiple_service
         }
     }
 
+    [ConditionalTheory] // #3375
+    [InlineData(false)]
+    [InlineData(true)]
+    public void MapEnum_configured_twice_by_context_and_factory_registrations(bool pooled)
+    {
+        // Registering both a context and a context factory runs both configuration lambdas against the same options,
+        // so the same MapEnum call is applied twice.
+        var serviceCollection = new ServiceCollection();
+        if (pooled)
+        {
+            serviceCollection.AddDbContextPool<EnumDbContext>(b => b.UseNpgsql("Host=localhost", o => o.MapEnum<Mood>()));
+            serviceCollection.AddPooledDbContextFactory<EnumDbContext>(b => b.UseNpgsql("Host=localhost", o => o.MapEnum<Mood>()));
+        }
+        else
+        {
+            serviceCollection.AddDbContext<EnumDbContext>(b => b.UseNpgsql("Host=localhost", o => o.MapEnum<Mood>()));
+            serviceCollection.AddDbContextFactory<EnumDbContext>(b => b.UseNpgsql("Host=localhost", o => o.MapEnum<Mood>()));
+        }
+
+        using var services = serviceCollection.BuildServiceProvider();
+
+        using (var scope = services.CreateScope())
+        {
+            AssertMoodMapped(scope.ServiceProvider.GetRequiredService<EnumDbContext>());
+        }
+
+        using var factoryContext = services.GetRequiredService<IDbContextFactory<EnumDbContext>>().CreateDbContext();
+        AssertMoodMapped(factoryContext);
+
+        static void AssertMoodMapped(EnumDbContext context)
+        {
+            var npgsqlOptions = context.GetService<IDbContextOptions>().FindExtension<NpgsqlOptionsExtension>()!;
+            var enumDefinition = Assert.Single(npgsqlOptions.EnumDefinitions);
+            Assert.Same(typeof(Mood), enumDefinition.ClrType);
+
+            var property = context.Model.FindEntityType(typeof(Person))!.FindProperty(nameof(Person.Mood))!;
+            Assert.Equal("mood", property.GetRelationalTypeMapping().StoreType);
+            Assert.Equal("mood", Assert.Single(context.GetService<IDesignTimeModel>().Model.GetPostgresEnums()).Name);
+        }
+    }
+
     private class ApplicationDbContext(DbContextOptions options) : DbContext(options);
+
+    private class EnumDbContext(DbContextOptions<EnumDbContext> options) : DbContext(options)
+    {
+        public DbSet<Person> People { get; set; }
+    }
+
+    private class Person
+    {
+        public int Id { get; set; }
+        public Mood Mood { get; set; }
+    }
+
+    private enum Mood
+    {
+        Happy,
+        Sad
+    }
 }
diff --git a/test/EFCore.PG.Tests/Storage/NpgsqlTypeMappingSourceTest.cs b/test/EFCore.PG.Tests/Storage/NpgsqlTypeMappingSourceTest.cs
index 492e720ae..3a70c9e7e 100644
--- a/test/EFCore.PG.Tests/Storage/NpgsqlTypeMappingSourceTest.cs
+++ b/test/EFCore.PG.Tests/Storage/NpgsqlTypeMappingSourceTest.cs
@@ -7,6 +7,7 @@
 using Npgsql.EntityFrameworkCore.PostgreSQL.Internal;
 using Npgsql.EntityFrameworkCore.PostgreSQL.Storage.Internal;
 using Npgsql.EntityFrameworkCore.PostgreSQL.Storage.Internal.Mapping;
+using Npgsql.NameTranslation;
 
 namespace Npgsql.EntityFrameworkCore.PostgreSQL.Storage;
 
@@ -348,7 +349,6 @@ public void Enum_mapping()
     }
 
     [Theory]
-    [InlineData("dummy_enum", null)]
     [InlineData("other_enum", null)]
     [InlineData("dummy_enum", "other")]
     public void Enum_with_multiple_definitions_for_clr_type(string secondName, string secondSchema)
@@ -361,10 +361,48 @@ public void Enum_with_multiple_definitions_for_clr_type(string secondName, strin
             Assert.Throws<InvalidOperationException>(() => source.FindMapping(typeof(DummyEnum))).Message);
     }
 
+    [Theory] // #3375
+    [InlineData(null)]
+    [InlineData("some_schema")]
+    public void Enum_mapped_twice_with_same_definition(string schema)
+    {
+        var source = CreateTypeMappingSource(
+            configure: b => b.MapEnum<DummyEnum>("dummy_enum", schema).MapEnum<DummyEnum>("dummy_enum", schema));
+        var storeType = schema is null ? "dummy_enum" : schema + ".dummy_enum";
+
+        Assert.Equal(storeType, source.FindMapping(typeof(DummyEnum)).StoreType);
+        Assert.Same(typeof(DummyEnum), source.FindMapping(storeType).ClrType);
+        Assert.Same(typeof(DummyEnum), source.FindMapping(typeof(DummyEnum), storeType).ClrType);
+    }
+
+    [Fact] // #3375
+    public void Enum_mapped_twice_with_equivalent_name_translators()
+    {
+        var source = CreateTypeMappingSource(
+            configure: b => b
+                .MapEnum<DummyEnum>(nameTranslator: new NpgsqlSnakeCaseNameTranslator())
+                .MapEnum<DummyEnum>(nameTranslator: new NpgsqlSnakeCaseNameTranslator()));
+
+        Assert.Equal("dummy_enum", source.FindMapping(typeof(DummyEnum)).StoreType);
+    }
+
+    [Fact]
+    public void Enum_mapped_twice_with_different_labels()
+    {
+        // Same CLR type and store type, but the name translators produce different labels ("value" vs. "Value"): this is a real
+        // conflict, so both definitions are kept and the lookup reports it.
+        var source = CreateTypeMappingSource(
+            configure: b => b
+                .MapEnum<DummyEnum>("dummy_enum", nameTranslator: new NpgsqlSnakeCaseNameTranslator())
+                .MapEnum<DummyEnum>("dummy_enum", nameTranslator: new NpgsqlNullNameTranslator()));
+
+        Assert.Equal(
+            $"Multiple enum definitions registered for CLR type '{typeof(DummyEnum).FullName}'.",
+            Assert.Throws<InvalidOperationException>(() => source.FindMapping(typeof(DummyEnum))).Message);
+    }
+
     [Theory]
-    [InlineData(null, null, "dummy_enum", typeof(DummyEnum))]
     [InlineData(null, null, "dummy_enum", typeof(OtherDummyEnum))]
-    [InlineData("test", "test", "test.dummy_enum", typeof(DummyEnum))]
     [InlineData("test", "test", "\"test\".\"dummy_enum\"", typeof(OtherDummyEnum))]
     [InlineData("one", "two", "dummy_enum", typeof(OtherDummyEnum))]
     public void Enum_with_multiple_definitions_for_store_type(