diff --git a/packages/grpc-js/src/retrying-call.ts b/packages/grpc-js/src/retrying-call.ts
index eaa609b40..4065f28f4 100644
--- a/packages/grpc-js/src/retrying-call.ts
+++ b/packages/grpc-js/src/retrying-call.ts
@@ -207,6 +207,7 @@ export class RetryingCall implements Call, DeadlineInfoProvider {
    */
   private attempts = 0;
   private hedgingTimer: NodeJS.Timeout | null = null;
+  private retryTimer: NodeJS.Timeout | null = null;
   private committedCallIndex: number | null = null;
   private initialRetryBackoffSec = 0;
   private nextRetryBackoffSec = 0;
@@ -321,6 +322,18 @@ export class RetryingCall implements Call, DeadlineInfoProvider {
         'cancelWithStatus code: ' + status + ' details: "' + details + '"'
       );
     }
+    /* No new attempt may start after cancellation. Otherwise a pending retry
+     * or hedging timer would start one, opening a stream that nothing will
+     * ever end. */
+    this.state = 'NO_RETRY';
+    if (this.retryTimer) {
+      clearTimeout(this.retryTimer);
+      this.retryTimer = null;
+    }
+    if (this.hedgingTimer) {
+      clearTimeout(this.hedgingTimer);
+      this.hedgingTimer = null;
+    }
     this.reportStatus({ code: status, details, metadata: new Metadata() });
     for (const { call } of this.underlyingCalls) {
       call.cancelWithStatus(status, details);
@@ -487,7 +500,8 @@ export class RetryingCall implements Call, DeadlineInfoProvider {
       retryDelayMs = pushback;
       this.nextRetryBackoffSec = this.initialRetryBackoffSec;
     }
-    setTimeout(() => {
+    this.retryTimer = setTimeout(() => {
+      this.retryTimer = null;
       if (this.state !== 'RETRY') {
         callback(false);
         return;
diff --git a/packages/grpc-js/test/test-retry.ts b/packages/grpc-js/test/test-retry.ts
index d7e5a09cd..e6321ac84 100644
--- a/packages/grpc-js/test/test-retry.ts
+++ b/packages/grpc-js/test/test-retry.ts
@@ -468,3 +468,145 @@ describe('Retries', () => {
     });
   });
 });
+
+describe('Retries after cancellation', () => {
+  /* Counts the attempts started for each call-id. Client streaming handlers
+   * run as soon as an attempt's headers arrive, so every attempt is counted. */
+  const attemptCounts = new Map<string, number>();
+  const cancellationServiceImpl = {
+    echo: (
+      call: grpc.ServerUnaryCall<any, any>,
+      callback: grpc.sendUnaryData<any>
+    ) => {
+      const id = call.metadata.get('call-id')[0] as string | undefined;
+      if (id) {
+        attemptCounts.set(id, (attemptCounts.get(id) ?? 0) + 1);
+        callback({ code: grpc.status.UNAVAILABLE, details: 'Unavailable' });
+      } else {
+        callback(null, call.request);
+      }
+    },
+    echoClientStream: (
+      call: grpc.ServerReadableStream<any, any>,
+      callback: grpc.sendUnaryData<any>
+    ) => {
+      const id = call.metadata.get('call-id')[0] as string;
+      attemptCounts.set(id, (attemptCounts.get(id) ?? 0) + 1);
+      callback({ code: grpc.status.UNAVAILABLE, details: 'Unavailable' });
+    },
+  };
+  const serviceConfig = {
+    loadBalancingConfig: [],
+    methodConfig: [
+      {
+        name: [{ service: 'EchoService' }],
+        retryPolicy: {
+          maxAttempts: 3,
+          initialBackoff: '0.3s',
+          maxBackoff: '0.3s',
+          backoffMultiplier: 1,
+          retryableStatusCodes: ['UNAVAILABLE'],
+        },
+      },
+    ],
+  };
+  let server: grpc.Server;
+  let client: InstanceType<grpc.ServiceClientConstructor>;
+  before(done => {
+    server = new grpc.Server({ 'grpc.max_concurrent_streams': 3 });
+    server.addService(EchoService.service, cancellationServiceImpl);
+    server.bindAsync(
+      'localhost:0',
+      grpc.ServerCredentials.createInsecure(),
+      (error, port) => {
+        if (error) {
+          done(error);
+          return;
+        }
+        client = new EchoService(
+          `localhost:${port}`,
+          grpc.credentials.createInsecure(),
+          { 'grpc.service_config': JSON.stringify(serviceConfig) }
+        );
+        done();
+      }
+    );
+  });
+
+  after(() => {
+    client.close();
+    server.forceShutdown();
+  });
+
+  function cancelDuringBackoff(
+    id: string,
+    streaming: boolean,
+    done: () => void
+  ) {
+    const metadata = new grpc.Metadata();
+    metadata.set('call-id', id);
+    let call: grpc.ClientWritableStream<any> | grpc.ClientUnaryCall;
+    if (streaming) {
+      const stream = client.echoClientStream(metadata, () => {});
+      stream.write({ value: 'test value', value2: 3 });
+      call = stream;
+    } else {
+      call = client.echo(
+        { value: 'test value', value2: 3 },
+        metadata,
+        () => {}
+      );
+    }
+    const waitForFirstAttempt = () => {
+      if (!attemptCounts.get(id)) {
+        setTimeout(waitForFirstAttempt, 5);
+        return;
+      }
+      // The first attempt failed; the retry is waiting out its backoff.
+      setTimeout(() => {
+        call.cancel();
+        done();
+      }, 50);
+    };
+    waitForFirstAttempt();
+  }
+
+  it('Should not start new attempts after the call is cancelled during backoff', done => {
+    cancelDuringBackoff('cancelled', true, () => {
+      setTimeout(() => {
+        assert.strictEqual(attemptCounts.get('cancelled'), 1);
+        done();
+      }, 1000);
+    });
+  });
+
+  it('Should not leak streams when calls are cancelled during backoff', done => {
+    let cancelled = 0;
+    for (let i = 0; i < 3; i++) {
+      /* A unary retry attempt started after cancellation has no message to
+       * send, so the server never responds and its stream stays open. */
+      cancelDuringBackoff(`leak-${i}`, false, () => {
+        cancelled += 1;
+        if (cancelled < 3) {
+          return;
+        }
+        // The server allows 3 concurrent streams. Leaked retry attempts would
+        // hold all of them, so this call could never start.
+        setTimeout(() => {
+          client.echo(
+            { value: 'test value', value2: 3 },
+            { deadline: Date.now() + 2000 },
+            (error: grpc.ServiceError, response: any) => {
+              assert.ifError(error);
+              assert.deepStrictEqual(response, {
+                value: 'test value',
+                value2: 3,
+              });
+              done();
+            }
+          );
+        }, 500);
+      });
+    }
+  });
+});