diff --git a/src/Autofac.Extras.DynamicProxy/RegistrationExtensions.cs b/src/Autofac.Extras.DynamicProxy/RegistrationExtensions.cs
index 68989f2..222ed48 100644
--- a/src/Autofac.Extras.DynamicProxy/RegistrationExtensions.cs
+++ b/src/Autofac.Extras.DynamicProxy/RegistrationExtensions.cs
@@ -164,7 +164,7 @@ public static IRegistrationBuilder<TLimit, TActivatorData, TSingleRegistrationSt
         {
             next(ctx);
 
-            EnsureInterfaceInterceptionApplies(ctx.Registration);
+            EnsureInterfaceInterceptionApplies(ctx.Service, ctx.Registration);
 
             // The instance won't ever _practically_ be null by the time it gets here.
             var proxiedInterfaces = ctx.Instance!
@@ -267,12 +267,15 @@ public static IRegistrationBuilder<TLimit, TActivatorData, TStyle> InterceptedBy
         return InterceptedBy(builder, interceptorServiceTypes.Select(t => new TypedService(t)).ToArray());
     }
 
-    private static void EnsureInterfaceInterceptionApplies(IComponentRegistration componentRegistration)
+    private static void EnsureInterfaceInterceptionApplies(Service service, IComponentRegistration componentRegistration)
     {
-        if (componentRegistration.Services
-            .OfType<IServiceWithType>()
-            .Select(s => new Tuple<Type, TypeInfo>(s.ServiceType, s.ServiceType.GetTypeInfo()))
-            .Any(s => !s.Item2.IsInterface || !ProxyUtil.IsAccessible(s.Item1)))
+        // Only the service actually being resolved needs to be a public interface.
+        // A registration may expose additional services (for example, the concrete
+        // type alongside an interface when scanning with AsClosedTypesOf) that are
+        // not interfaces; those are irrelevant when interception is applied to an
+        // interface service. See issue #27.
+        if (service is IServiceWithType serviceWithType &&
+            (!serviceWithType.ServiceType.GetTypeInfo().IsInterface || !ProxyUtil.IsAccessible(serviceWithType.ServiceType)))
         {
             throw new InvalidOperationException(
                 string.Format(
diff --git a/test/Autofac.Extras.DynamicProxy.Test/OpenGenericInterfaceInterceptionFixture.cs b/test/Autofac.Extras.DynamicProxy.Test/OpenGenericInterfaceInterceptionFixture.cs
new file mode 100644
index 0000000..72ed67e
--- /dev/null
+++ b/test/Autofac.Extras.DynamicProxy.Test/OpenGenericInterfaceInterceptionFixture.cs
@@ -0,0 +1,97 @@
+// Copyright (c) Autofac Project. All rights reserved.
+// Licensed under the MIT License. See LICENSE in the project root for license information.
+
+using Autofac.Core;
+using Castle.DynamicProxy;
+using IInvocation = Castle.DynamicProxy.IInvocation;
+
+namespace Autofac.Extras.DynamicProxy.Test;
+
+public class OpenGenericInterfaceInterceptionFixture
+{
+    public interface ICommandHandler<TCommand, TResult>
+    {
+        TResult Handle(TCommand command);
+    }
+
+    [Fact]
+    public void InterceptsClosedTypesOfScannedOpenGenericInterface()
+    {
+        // Issue #27: When scanning an assembly and registering closed types of an
+        // open generic interface, interface interception should still work even
+        // though the scan also registers the concrete type as a service.
+        var builder = new ContainerBuilder();
+        builder.RegisterType<StringMethodInterceptor>();
+        builder
+            .RegisterAssemblyTypes(typeof(OpenGenericInterfaceInterceptionFixture).Assembly)
+            .AsClosedTypesOf(typeof(ICommandHandler<,>))
+            .EnableInterfaceInterceptors()
+            .InterceptedBy(typeof(StringMethodInterceptor));
+        var container = builder.Build();
+
+        var handler = container.Resolve<ICommandHandler<string, string>>();
+
+        Assert.Equal("intercepted-Handle", handler.Handle("input"));
+    }
+
+    [Fact]
+    public void InterceptsInterfaceServiceWhenRegistrationAlsoExposesConcreteType()
+    {
+        // A registration can expose both the concrete type and an interface. When
+        // resolved by the interface, interception should apply even though the
+        // concrete type is not an interface.
+        var builder = new ContainerBuilder();
+        builder.RegisterType<StringMethodInterceptor>();
+        builder
+            .RegisterType<StringCommandHandler>()
+            .AsSelf()
+            .As<ICommandHandler<string, string>>()
+            .EnableInterfaceInterceptors()
+            .InterceptedBy(typeof(StringMethodInterceptor));
+        var container = builder.Build();
+
+        var handler = container.Resolve<ICommandHandler<string, string>>();
+
+        Assert.Equal("intercepted-Handle", handler.Handle("input"));
+    }
+
+    [Fact]
+    public void ThrowsWhenResolvingConcreteServiceWithInterfaceInterception()
+    {
+        // Resolving the non-interface service directly cannot be proxied via
+        // interface interception and must still throw, even when the registration
+        // also exposes an interface service.
+        var builder = new ContainerBuilder();
+        builder.RegisterType<StringMethodInterceptor>();
+        builder
+            .RegisterType<StringCommandHandler>()
+            .AsSelf()
+            .As<ICommandHandler<string, string>>()
+            .EnableInterfaceInterceptors()
+            .InterceptedBy(typeof(StringMethodInterceptor));
+        var container = builder.Build();
+
+        var dx = Assert.Throws<DependencyResolutionException>(() => container.Resolve<StringCommandHandler>());
+        Assert.IsType<InvalidOperationException>(dx.InnerException);
+    }
+
+    public class StringCommandHandler : ICommandHandler<string, string>
+    {
+        public string Handle(string command) => command;
+    }
+
+    private class StringMethodInterceptor : IInterceptor
+    {
+        public void Intercept(IInvocation invocation)
+        {
+            if (invocation.Method.ReturnType == typeof(string))
+            {
+                invocation.ReturnValue = "intercepted-" + invocation.Method.Name;
+            }
+            else
+            {
+                invocation.Proceed();
+            }
+        }
+    }
+}