diff --git a/python/pyarrow/_compute.pyx b/python/pyarrow/_compute.pyx
index 1c0c779f6037..b166bc9bf7cd 100644
--- a/python/pyarrow/_compute.pyx
+++ b/python/pyarrow/_compute.pyx
@@ -2708,7 +2708,7 @@ cdef class Expression(_Weakrefable):
     cdef inline CExpression unwrap(self):
         return self.expr
 
-    def equals(self, Expression other):
+    def equals(self, Expression other not None):
         """
         Parameters
         ----------
diff --git a/python/pyarrow/_dataset.pyx b/python/pyarrow/_dataset.pyx
index d40614a61fc0..f5666d69e1dd 100644
--- a/python/pyarrow/_dataset.pyx
+++ b/python/pyarrow/_dataset.pyx
@@ -4052,7 +4052,7 @@ cdef class Scanner(_Weakrefable):
         return reader
 
 
-def get_partition_keys(Expression partition_expression):
+def get_partition_keys(Expression partition_expression not None):
     """
     Extract partition keys (equality constraints between a field and a scalar)
     from an expression as a dict mapping the field's name to its value.
diff --git a/python/pyarrow/tests/test_compute.py b/python/pyarrow/tests/test_compute.py
index 797fbc220ec3..2ccef3ac6eb3 100644
--- a/python/pyarrow/tests/test_compute.py
+++ b/python/pyarrow/tests/test_compute.py
@@ -4249,6 +4249,9 @@ def test_expression_construction():
     with pytest.raises(TypeError):
         field.isin(1)
 
+    with pytest.raises(TypeError, match="Argument 'other' has incorrect type"):
+        field.equals(None)
+
     with pytest.raises(pa.ArrowInvalid):
         field != object()
 
diff --git a/python/pyarrow/tests/test_dataset.py b/python/pyarrow/tests/test_dataset.py
index 0a94c0bd9875..707d937da201 100644
--- a/python/pyarrow/tests/test_dataset.py
+++ b/python/pyarrow/tests/test_dataset.py
@@ -946,6 +946,9 @@ def test_partition_keys():
     null = ds.field('a').is_null()
     assert ds.get_partition_keys(null) == {'a': None}
 
+    with pytest.raises(TypeError, match="Argument 'partition_expression'"):
+        ds.get_partition_keys(None)
+
 
 @pytest.mark.parquet
 def test_parquet_read_options():
diff --git a/python/pyarrow/tests/test_misc.py b/python/pyarrow/tests/test_misc.py
index 856873f441b4..0d755e25297b 100644
--- a/python/pyarrow/tests/test_misc.py
+++ b/python/pyarrow/tests/test_misc.py
@@ -270,3 +270,21 @@ def test_extension_type_constructor_errors(klass):
     msg = f"Do not call {klass.__name__}'s constructor directly, use .* instead."
     with pytest.raises(TypeError, match=msg):
         klass()
+
+
+@pytest.mark.processes
+@pytest.mark.dataset
+@pytest.mark.parametrize(("call", "argument"), [
+    ("ds.get_partition_keys(None)", "partition_expression"),
+    ("ds.field('a').equals(None)", "other"),
+])
+def test_expression_apis_reject_none_without_crashing(
+        call: str, argument: str) -> None:
+    code = f"""if 1:
+        import pytest
+        import pyarrow.dataset as ds
+
+        with pytest.raises(TypeError, match="Argument '{argument}'"):
+            {call}
+        """
+    subprocess.check_call(args=[sys.executable, "-c", code], timeout=30)