Convert more single compartment cell models of Pospischil et al. 2008

[pgleeson]

Brief description

The conversion of cell models from Minimal Hodgkin–Huxley type models for different classes of cortical and thalamic neurons, Martin Pospischil, Maria Toledo-Rodriguez, Cyril Monier, Zuzanna Piwkowska, Thierry Bal, Yves Frégnac, Henry Markram and Alain Destexhe, Biological Cybernetics, 2008 requires more work.

See https://github.com/OpenSourceBrain/PospischilEtAl2008

Expected result

Reproducing most of the figures in the paper with models in pure NeuroML2.

Suggested steps

Note: there has been progress converting this model to ChannelML and using it in a neuroConstruct project. However, working on expressing the channels and cells in NeuroML2 and developing LEMS models to run these (and potentially pyNeuroML scripts to generate FI curves) should be more productive in the short term.

• Test existing implementation of channels in NeuroML2 against original mod files. Use (pynml-channelanalysis/pynml-modchananalysis).
• Ensure first cell model (RS cell) behaves same as example from ModelDB. See Get RS cell to match original NEURON code PospischilEtAl2008#3
• Implement other channels in similar fashion (L & T type Ca2+)
• Implement other cell models in NML2 as can be generated from ModelDB example script
• Implement scripts for figures from the paper

Possible extensions

More details to be added...

Knowledge prerequisites

NeuroML2/LEMS

To be learned

Conductance based modelling of cortical cells

Mentor

Contact p.gleeson -at- ucl.ac.uk if you are interested in contributing to this task

[pgleeson]

@JustasB will work on this.

[JustasB]

@pgleeson While we're waiting on Victoria for the PinskyRinsel model, I would like to start working on this model. Will you please add additional detail to this issue?

[JustasB]

RS and FS cells implemented here: OpenSourceBrain/PospischilEtAl2008#4

[pgleeson]

More details on the current status of this can be found in the issues list for the project