diff --git a/docs/changes.rst b/docs/changes.rst
index fc7fc406..f27c7d49 100644
--- a/docs/changes.rst
+++ b/docs/changes.rst
@@ -20,6 +20,9 @@ Unreleased
 **Build with uv_build**
   The package is now built with ``uv_build`` instead of ``hatchling``. The version number is specified in ``pyproject.toml`` only, and ``wfdb.__version__`` is read from the installed package metadata (it is ``"unknown"`` if the package is run from a source tree without being installed).
 
+**Speed up XQRS backsearch**
+  ``XQRS`` no longer rechecks peaks that an earlier backsearch already rejected. Long stretches without QRS complexes (for example a disconnected lead) made detection take quadratic time, up to hours on long records. The detected QRS locations are unchanged.
+
 **Use Ruff for formatting and linting**
   The ``dev`` extra now includes ``ruff`` instead of ``black`` and ``pylint``, and the code is formatted with a line length of 88 (the default).
 
diff --git a/src/wfdb/processing/qrs.py b/src/wfdb/processing/qrs.py
index f81ec65b..022ac219 100644
--- a/src/wfdb/processing/qrs.py
+++ b/src/wfdb/processing/qrs.py
@@ -610,11 +610,16 @@ def _backsearch(self):
 
         """
         if self.last_qrs_peak_num is not None:
-            for peak_num in range(self.last_qrs_peak_num + 1, self.peak_num + 1):
+            # Skip peaks a previous backsearch already rejected. Their result
+            # can only change after a QRS update, which moves
+            # last_qrs_peak_num past them.
+            start = max(self.last_qrs_peak_num, self._backsearch_peak_num) + 1
+            for peak_num in range(start, self.peak_num + 1):
                 if self._is_qrs(peak_num=peak_num, backsearch=True):
                     self._update_qrs(peak_num=peak_num, backsearch=True)
                 # No need to update noise parameters if it was classified as
                 # noise. It would have already been updated.
+            self._backsearch_peak_num = self.peak_num
 
     def _run_detection(self):
         """Run the QRS detection after the signals and parameters have been set.
@@ -635,6 +640,8 @@ def _run_detection(self):
         self.qrs_inds = []
         # QRS indices found via backsearch
         self.backsearch_qrs_inds = []
+        # Last peak number checked by a backsearch
+        self._backsearch_peak_num = -1
 
         # Iterate through MWI signal peak indices
         for self.peak_num in range(self.n_peaks_i):
diff --git a/tests/test_processing.py b/tests/test_processing.py
index 1d5a6379..fe1ca4c9 100644
--- a/tests/test_processing.py
+++ b/tests/test_processing.py
@@ -192,6 +192,35 @@ def test_xqrs(self):
         assert comparitor.sensitivity > 0.99
         assert comparitor.positive_predictivity > 0.99
 
+    def test_xqrs_backsearch_checks_each_peak_once(self):
+        """Backsearch does not recheck rejected peaks in a gap (issue #352)."""
+        sig, fields = wfdb.rdsamp("sample-data/100", channels=[0])
+        fs = fields["fs"]
+        x = sig[:, 0]
+        # Beats, then low-amplitude noise (as from a disconnected lead), then beats
+        rng = np.random.default_rng(0)
+        gap = 0.01 * rng.standard_normal(120 * fs)
+        y = np.concatenate([x[: 30 * fs], gap, x[30 * fs : 60 * fs]])
+
+        xqrs = processing.XQRS(sig=y, fs=fs)
+        checked = []
+        is_qrs = xqrs._is_qrs
+
+        def spy(peak_num, backsearch=False):
+            if backsearch:
+                checked.append(peak_num)
+            return is_qrs(peak_num, backsearch=backsearch)
+
+        with mock.patch.object(xqrs, "_is_qrs", side_effect=spy):
+            xqrs.detect(verbose=False)
+
+        assert len(checked) > 0
+        assert len(checked) == len(set(checked))
+        # Beats on both sides of the gap are still found
+        n_before = np.sum(xqrs.qrs_inds < 30 * fs)
+        n_after = np.sum(xqrs.qrs_inds > 150 * fs)
+        assert n_before > 30 and n_after > 30
+
 
 class TestXQRSDetect:
     """Tests for the xqrs_detect convenience wrapper."""