diff --git a/manifests/python_lambda.yml b/manifests/python_lambda.yml
index ef76c50362c..3affdc315bf 100644
--- a/manifests/python_lambda.yml
+++ b/manifests/python_lambda.yml
@@ -266,7 +266,7 @@ manifest:
   tests/appsec/test_reports.py::Test_Info: v7.112.0
   tests/appsec/test_reports.py::Test_RequestHeaders: v7.112.0
   tests/appsec/test_reports.py::Test_StatusCode: v7.112.0
-  tests/appsec/test_sca_reachability.py: incomplete_test_app (Lambda SCA dependency fixtures and vulnerable-call endpoints are not implemented)
+  tests/appsec/test_sca_reachability.py: missing_feature (requires Lambda SCA reachability support in dd-trace-py and datadog-lambda-python)
   tests/appsec/test_trace_tagging.py::Test_TraceTaggingRules: v8.113.0
   tests/appsec/test_traces.py::Test_AppSecEventSpanTags: v7.112.0
   tests/appsec/test_traces.py::Test_AppSecEventSpanTags::test_header_collection: bug (APPSEC-58202)
diff --git a/tests/appsec/sca_advisories.json b/tests/appsec/sca_advisories.json
new file mode 100644
index 00000000000..186d812b022
--- /dev/null
+++ b/tests/appsec/sca_advisories.json
@@ -0,0 +1,26 @@
+{
+  "targets": [
+    {
+      "id": "system-tests-sca",
+      "lang": "python",
+      "dependency_name": "requests",
+      "package_versions": [
+        ">=0"
+      ],
+      "targets": [
+        "requests.sessions:Session.send"
+      ]
+    },
+    {
+      "id": "system-tests-sca",
+      "lang": "maven",
+      "dependency_name": "com.github.junrar:junrar",
+      "package_versions": [
+        ">=0"
+      ],
+      "targets": [
+        "com.github.junrar:LocalFolderExtractor.createDirectory"
+      ]
+    }
+  ]
+}
diff --git a/tests/appsec/test_sca_reachability.py b/tests/appsec/test_sca_reachability.py
index aef5a54ef42..e494e3eddfc 100644
--- a/tests/appsec/test_sca_reachability.py
+++ b/tests/appsec/test_sca_reachability.py
@@ -33,6 +33,12 @@
         "path": "com.datadoghq.system_tests.springboot.ScaReachability",
         "symbol": "junrarHit",
     },
+    "python_lambda": {
+        "cve_id": ["system-tests-sca"],
+        "vulnerable_dep": "requests",
+        "path": "handler.py",
+        "symbol": "sca_requests_vulnerable_call",
+    },
     "java_lambda": {
         "cve_id": ["GHSA-hf5p-q87m-crj7"],
         "vulnerable_dep": "junrar",
diff --git a/utils/_context/_scenarios/aws_lambda.py b/utils/_context/_scenarios/aws_lambda.py
index 30919185d00..4a0aad1a59f 100644
--- a/utils/_context/_scenarios/aws_lambda.py
+++ b/utils/_context/_scenarios/aws_lambda.py
@@ -215,7 +215,11 @@ class AppsecLambdaSca(_LambdaScenario):
     def __init__(self) -> None:
         super().__init__(
             "APPSEC_LAMBDA_SCA",
-            weblog_env={"DD_APPSEC_ENABLED": "false", "DD_APPSEC_SCA_ENABLED": "true"},
+            weblog_env={
+                "DD_APPSEC_ENABLED": "false",
+                "DD_APPSEC_SCA_ENABLED": "true",
+            },
+            weblog_volumes={"./tests/appsec/sca_advisories.json": {"bind": "/sca_advisories.json", "mode": "ro"}},
             doc="SCA dependency metadata and runtime reachability in Lambda with AppSec disabled",
             scenario_groups=[scenario_groups.appsec, scenario_groups.appsec_lambda],
         )
diff --git a/utils/build/docker/python_lambda/function/app.sh b/utils/build/docker/python_lambda/function/app.sh
index eb958bd98f3..96c28071310 100644
--- a/utils/build/docker/python_lambda/function/app.sh
+++ b/utils/build/docker/python_lambda/function/app.sh
@@ -4,6 +4,22 @@ set -eu
 
 export DD_LAMBDA_HANDLER=handler.lambda_handler
 
+# Only the SCA scenario mounts this catalog. Install its Python entries before
+# starting the Lambda wrapper, which initializes reachability instrumentation.
+if [ -f /sca_advisories.json ]; then
+    python3 - <<'PY'
+import json
+from pathlib import Path
+
+catalog = json.loads(Path("/sca_advisories.json").read_text())
+targets = [entry for entry in catalog["targets"] if entry["lang"] == "python"]
+data_paths = list(Path("/opt/python").glob("lib/python*/site-packages/ddtrace/appsec/sca/_cve_data.json"))
+if len(data_paths) != 1:
+    raise RuntimeError(f"Expected one bundled SCA catalog, found {data_paths}")
+data_paths[0].write_text(json.dumps({"targets": targets}))
+PY
+fi
+
 socat TCP-LISTEN:8127,reuseaddr,fork,bind=0.0.0.0 TCP:127.0.0.1:8126 &
 
 exec /lambda-entrypoint.sh datadog_lambda.handler.handler
diff --git a/utils/build/docker/python_lambda/function/handler.py b/utils/build/docker/python_lambda/function/handler.py
index d507f927a20..875f4be39e4 100644
--- a/utils/build/docker/python_lambda/function/handler.py
+++ b/utils/build/docker/python_lambda/function/handler.py
@@ -47,6 +47,28 @@
 _TRACK_CUSTOM_APPSEC_EVENT_NAME = "system_tests_appsec_event"
 
 
+@app.get("/sca/vulnerable-call")
+def sca_requests_vulnerable_call() -> str:
+    """Exercise the synthetic advisory's Session.send target."""
+    with requests.Session() as session:
+        try:
+            session.send(requests.Request("GET", "http://127.0.0.1:1").prepare(), timeout=1)
+        except requests.exceptions.ConnectionError:
+            pass
+    return "OK"
+
+
+@app.get("/sca/vulnerable-call-alt")
+def sca_requests_vulnerable_call_alt() -> str:
+    """Use a distinct caller for the same target to check first-hit deduplication."""
+    with requests.Session() as session:
+        try:
+            session.send(requests.Request("GET", "http://127.0.0.1:1").prepare(), timeout=1)
+        except requests.exceptions.ConnectionError:
+            pass
+    return "OK"
+
+
 def version_info():
     return {
         "status": "ok",
diff --git a/utils/scripts/libraries_and_scenarios_rules.yml b/utils/scripts/libraries_and_scenarios_rules.yml
index 806149e4c5d..31f60a3c861 100644
--- a/utils/scripts/libraries_and_scenarios_rules.yml
+++ b/utils/scripts/libraries_and_scenarios_rules.yml
@@ -589,7 +589,12 @@ patterns:
 
     tests/appsec/test_sca_reachability.py:
         scenario_groups: null
-        libraries: [java, java_lambda, python]
+        libraries: [java, java_lambda, python, python_lambda]
+
+    tests/appsec/sca_advisories.json:
+        scenario_groups: null
+        scenarios: [APPSEC_LAMBDA_SCA]
+        libraries: python_lambda
 
 ################################# Default rules ################################
 # The rules in this section are only applied if no other rule is applicable.