Skip to content

Estimation of evolutionary rates #1739

Description

@glstott

(Zenhub issue 187)

We want to extend MicrobeTrace to support estimation of evolutionary (molecular clock) rates from sequence-associated data. This will enable users to quantify the rate of genetic change over time and support downstream epidemiological interpretations (e.g., transmission timing, outbreak dynamics, and validation of clustering thresholds).

Will work on data that has
Molecular distances AND sample collection dates (required for rate estimation)

Acceptance Criteria

  • Users can compute an evolutionary rate when sequence distances and dates are present
  • Results update dynamically based on filters/subsets
  • Regression plot renders correctly with labeled axes and slope
  • Outputs include rate, R², and sample size
  • System handles missing/invalid dates gracefully
  • Computation performs within acceptable time for typical dataset sizes
  • Results can be exported

Activity

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment

Metadata

Metadata

Labels

Epic[effort] largeSomething that's really difficult, given the current state of MicrobeTraceenhancement

Type

No type

Projects

No projects

    Milestone

    No milestone

    Relationships

    None yet

    Development

    No branches or pull requests

    Issue actions